Thursday, October 21, 2010

PEG-PCL biocompatibilty

The study below highlights some of the capabilities of polyethylene glycol block for improving biocompatibility of the polymer. Check out www.polyvivo.com to learn more.(note the below study was not necessarily performed using a PolySciTech product).


"In this study, we prepared diblock copolymers of poly([var epsilon]-caprolactone) (PCL) and poly(ethylene glycol) (PEG) by aluminum alkoxide catalysts. The biological responses to the spin cast surface of different PCL/PEG diblock copolymers were investigated in vitro. Our results showed that surface hydrophilicity improved with the increased PEG segments in diblock copolymers and that bacteria adhesion was inhibited by increased PEG contents. PCL-PEG 23:77 showed nanotopography on the surface. The number of adhered endothelial cells, platelets and monocytes on diblock copolymer surfaces was inhibited in PCL-PEG 77:23 and enhanced in PCL-PEG 23:77. Nevertheless, the platelet and monocyte activation on PCL-PEG 23:77 was reduced. PCL-PEG 23:77 had better cellular response as well as lower degree of platelet and monocyte activation. The current study was the first one to demonstrate that surface nanotopography could influence not only cell adhesion and growth but also platelet and monocyte activation."




S.-H. Hsu, C.-M. Tang, C.C.C.-C. Lin, Biocompatibility of poly([var epsilon]-caprolactone)/poly(ethylene glycol) diblock copolymers with nanophase separation. Biomaterials 25(25) (2004) 5593-5601. http://www.sciencedirect.com/science/article/B6TWB-4BWCBWW-2/2/d44c205286fb3dafb38030138b147abb
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