The thermogelation properties of low molecular weight triblock copolymers (like PolyVivo AK12 and AK19) can be fine-tuned using either PEG1000 to slightly lower the gelation temperature or NaSCN to raise the gelation temperature. PolyVivo polymers can be purchased at http://www.polyscitech.com/products/polyvivo/
The tuning process is described more thoroughly in the following research paper:
Myung Seob Shim, Hyung Tak Lee, Woo Sun Shim, Insun Park, Hyunjung Lee, Taihyun Chang,Sung Wan Kim, Doo Sung Lee “Poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly (D,L-lactic acid-co-glycolic acid) triblock copolymer and thermoreversible phase transition in water” J Biomed Mater Res 61: 188–196, 2002
Link To Full-text
http://www.postech.ac.kr/chem/poly/pdf/112.pdf
No comments:
Post a Comment