Friday, April 27, 2012

PEG-PLGA overview

A good overview article regarding the use of pegylated PLGA and other copolymers of this type is available here.
Abstract
"Over the past few decades, biodegradable polyesters, such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and poly(lactic-co-glycolic acid) (PLGA), have been extensively studied for a wide variety of pharmaceutical and biomedical applications. The biodegradable polyester family has been regarded as one of the few synthetic biodegradable polymers with controllable biodegradability, excellent biocompatibility, and high safety. The need for a variety of drug formulations for different drugs and delivery pathways resulted in development of various types of block copolymers (eg, diblock, triblock, multiblock, and star-shaped block) consisting of the biodegradable polyesters and poly(ethylene glycol) (PEG). Extensive studies throughout the world have produced encouraging results demonstrating many desirable, unique properties of PLGA-PEG block copolymers. Despite successes in preclinical applications and ever-increasing uses in diverse research activities, PLGA-PEG block copolymers are currently not available commercially. Recognizing that demands for PLGA-PEG block copolymers in pharmaceutical and biomedical applications will continue to grow, Akina, Inc., (www.akinainc.com/polycelle) has started production of PLGA-PEG block copolymers for those who want to use the block copolymers but are not willing to synthesize themselves. This article describes synthesis of PLGA-PEG block copolymers and their applications as drug delivery vehicles, such as micro/nano-particles, micelles, hydrogels, and injectable delivery systems."
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