Friday, June 22, 2012
PolyVivo AK36 thermogel injectability
Polyvivo AK36 is an injectable thermogel with high-longevity in-vivo due to a slowly degrading polycaprolactone block. dissolution of this material requires that it first be slurried into water at 4C then dissolved at 80C with stirring to break-down the PCL crystalline domains and subsequently chilled back to 4C overnight to equilibriate. The resultant solution (20% w/v) has thermogellation properties suitable for solidification in the body. As shown in the video the room-temperature solution can be injected through even a 27Ga needle.