Blog dedicated to answering technical questions in an open format relating to PolySciTech (A division of Akina, Inc.) products.
Friday, June 22, 2012
PolyVivo AK36 thermogel injectability
New product Polyvivo AK36 is an injectable thermogel with high-longevity in-vivo due to a slowly degrading polycaprolactone block. dissolution of this material requires that it first be slurried into water at 4C then dissolved at 80C with stirring to break-down the PCL crystalline domains and subsequently chilled back to 4C overnight to equilibriate. The resultant solution (20% w/v) has thermogellation properties suitable for solidification in the body. As shown in the video the room-temperature solution can be injected through even a 27Ga needle.