Blog dedicated to answering technical questions in an open format relating to PolySciTech (A division of Akina, Inc.) products.
Wednesday, February 13, 2013
mPEG-PCL, PCL-PEG-PCL thermogels
In addition to PLGA/PEG based thermogels such as AK12 and AK24, PolySciTech also carries PCL/PEG based thermogels. These include AK35 (PCL-PEG-PCL triblock) and AK36 (mPEG-PCL diblock).
These perform a little differently than the PLGA-PEG-PLGA blocks. Traditionally the AK12 and AK24 polymers dissolve over the course of 2-3 days with shaking or stirring at low temperature (5C) to become clear, water-like, solutions. Due to increased hydrophobicity/crystallinity the PCL based thermogels AK35 and AK36 require, in addition to 2-3 days of shaking at low temperture, about 30minutes of stirring at a high temperature (80C) to fully dissolve. Afterwards upon recooling the material forms into an opaque solution which shows increased gelation (notable rise in G'/G") upon warming.