Recent article describes the impact of mPEG-poly(lactide) chirality (L vs D) on solubilization of an antibiotic drug compound. It was found that D-sugar form of the drug solubilizes significantly better in the poly(D-Lactide) than the poly(L-lactide) indicating an impact of chirality for solubilization.
Objectives Although drug solubilization by block copolymer micelles has been extensively studied, the rationale behind the choice of appropriate block copolymer micelles for various poorly water-soluble drugs has been of relatively less concern. The objective of this study was to use methoxy-poly(ethylene glycol)-polylactate micelles (MPEG-PLA) to solubilize glycosylated antibiotic nocathiacin I and to compare the effects of chirality on the enhancement of aqueous solubility. Methods Nocathiacin I-loaded MPEG-PLA micelles with opposite optical property in PLA were synthesized and characterized. The drug release profile, micelle stability and preliminary safety properties of MPEG-PLA micelles were evaluated. Meanwhile, three other poorly water-soluble chiral compound-loaded micelles were also prepared and compared. Key findings The aqueous solubility of nocathiacin I was greatly enhanced by both l- and d-copolymers, with the degree of enhancement appearing to depend on the chirality of the copolymers. Comparison of different chiral compounds confirmed the trend that aqueous solubility of chiral compounds can be more effectively enhanced by block copolymer micelles with specific stereochemical configuration. Conclusions The present study introduced chiral concept on the selection and preparation of block copolymer micelles for the enhancement of aqueous solubility of poorly water-soluble drugs.
see more at http://onlinelibrary.wiley.com/doi/10.1111/j.2042-7158.2012.01576.x/full