Friday, May 3, 2013

PolyVivo AK10 nanoparticles with PEGylated surface


Recent report published by Ebbesen et. al. shows impact of co-formulation methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide) (5000-10000Da) (PolyVivo AK10) with PLGA (Medisorb 2A: 13kDa 53:47 LA:GA) on the resultant nanoparticle formulations at 0%(control), 6%, 30% w/w (AK10/PLGA).  Table below shows resulting data obtained from these nanoparticles.

*-values from Ebbesen et. al. 2013.  (±STDEV)

 Additionally the AK10 incorporating and control nanoparticles were tested against RAW 264.7 macrophage cells for cellular uptake and the AK10 incorporating particles were observed to have 70% less cellular uptake than control PLGA nanoparticles.  For more information check out the article: Ebbesen, M. F., et al. "Surface Analysis of PEGylated Nano-Shields on Nanoparticles Installed by Hydrophobic Anchors." Pharmaceutical research (2013): 1-10. (http://link.springer.com/article/10.1007/s11095-013-1018-3#)
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