Tuesday, January 14, 2014

Polyvivo AK36 mPEG-PCL

PolySciTech provides thermogelling block copolymers of methoxypoly(ethylene glycol)-b-polycaprolactone (mPEG-PCL (750-2400Da) (PolyVivo AK36). Recently similar polymer was utilized to effectively deliver doxycycline in a mouse model and was shown to effectively treat implanted cancer cells when used as an injectable drug delivery depot formulation. Kang, Yun Mi, Gyeong Hae Kim, Jae Il Kim, Da Yeon Kim, Bit Na Lee, So Mi Yoon, Jae Ho Kim, and Moon Suk Kim. "In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly (ethylene glycol)-b-polycaprolactone diblock copolymer." Biomaterials 32, no. 20 (2011): 4556-4564. http://www.sciencedirect.com/science/article/pii/S014296121100247X
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