Tuesday, February 11, 2014

Bone Scaffold PLLA PCL

PolySciTech (www.polyscitech.com) offers a wide variety of poly(lactides) and polycaprolactones in the AP** catalog series. Similar polymers have recently been blended together and made into porous constructs via salt-leaching. These constructs proved themselves potentially useful for application as a bone-tissue graft someday.  Read more at: Sadiasa, Alexander, Thi Hiep Nguyen, and Byong-Taek Lee. "In vitro and in vivo evaluation of porous PCL-PLLA 3D polymer scaffolds fabricated via salt leaching method for bone tissue engineering applications." Journal of Biomaterials Science, Polymer Edition 25, no. 2 (2014): 150-167. http://www.tandfonline.com/doi/abs/10.1080/09205063.2013.846633#.UvpEtPldUfU


“ABSTRACT: Three dimensional porous scaffolds composed of various ratios of polycaprolactone and poly(L-lactic acid) (PLLA) were prepared using salt leaching method for bone regeneration applications. Surfaces of the scaffolds were visualized using scanning electron microscope (SEM) and the combination of the polymers was confirmed by FT-IR. Addition of PLLA increased the porosity and pore sizes of the scaffolds and also the scaffolds’ compressive strength initially. Osteoblast-like cells were used and it was found that the samples’ cell biocompatibility was further promoted with the increase in PLLA content as observed via cell proliferation assays using MTT, gene expression with RT-PCR, and micrographs from SEM and confocal microscopy. Samples were then implanted into male rabbits for 2 months, and histological staining and micro-CT histomorphometry show that new bone formations were detected in the site containing the implants of the scaffolds and that bone regeneration was further promoted with the increased concentration of PLLA in the scaffold.” 
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