Monday, February 17, 2014

PLGA-PEG-PLGA cyclodextrin based hydrogels

PolySciTech (www.polyscitech.com) provides thermogelling PLGA-PEG-PLGA triblock copolymers including Polyvivo AK12 and AK24. Recently, similar polymers have been shown to form inclusion-complex based supramolecular hydrogels when interacting with cyclodextrin and that these hydrogels can be used for drug delivery. Read more at: Khodaverdi, Elham, Farnaz Sadat Mirzazadeh Tekie, Farzin Hadizadeh, Haydar Esmaeel, Seyed Ahmad Mohajeri, Sayyed A. Sajadi Tabassi, and Gholamhossein Zohuri. "Hydrogels Composed of Cyclodextrin Inclusion Complexes with PLGA-PEG-PLGA Triblock Copolymers as Drug Delivery Systems." AAPS PharmSciTech 15, no. 1 (2014): 177-188. http://link.springer.com/article/10.1208/s12249-013-0051-1


“Abstract: Although conventional pharmaceuticals have many drug dosage forms on the market, the development of new therapeutic molecules and the low efficacy of instant release formulations for the treatment of some chronic diseases and specific conditions encourage scientists to invent different delivery systems. To this purpose, a supramolecular hydrogel consisting of the tri-block copolymer PLGA-PEG-PLGA and α-cyclodextrin was fabricated for the first time and characterised in terms of rheological, morphological, and structural properties. Naltrexone hydrochloride and vitamin B12 were loaded, and their release profiles were determined.”
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