Thursday, April 3, 2014

mPEG-PCL for DOX/PTX chemotherapeutic co-delivery

PolySciTech (www.polyscitech.com) provides a variety of mPEG-PCLs including several new products AK73-AK75 which are varying block weights of mPEG-PCL.  Recently these types of polymers have been utilized as part of a paclitaxel and doxorubicin micelle delivery system showing a synergistic effect between these two drugs. Read more: Wang, Yan, Shurong Ma, Zhongshi Xie, and Haishan Zhang. "A synergistic combination therapy with paclitaxel and doxorubicin loaded micellar nanoparticles." Colloids and Surfaces B: Biointerfaces 116 (2014): 41-48. http://dx.doi.org/10.1016/j.colsurfb.2013.12.051

“Abstract: Doxorubicin was chemically conjugated to a biodegradable polymeric carrier as a polymer-doxorubicin (polymer-Dox) conjugate via an acid labile Schiff-base bond. Then, paclitaxel was physically encapsulated by the polymer-Dox conjugate to self assemble in water as micellar nanoparticles with both doxorubicin and paclitaxel in one nanoparticle. In this way, doxorubicin and paclitaxel were combined. The preparation of the polymer-doxorubicin conjugates, encapsulation of paclitaxel, characterization of nanoparticles was systematically studied and the biological evaluation of the free drug combination as well as the micellar platform combination in vitro was thoroughly detailed. Keywords: Combination therapy; Nanoparticles; Drug delivery; Paclitaxel; Doxorubicin”

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