Tuesday, May 13, 2014

PolySciTech PLGA used for Magnesium implant coatings

PolySciTech (www.polyscitech.com) provides a wide array of PLGA’s. Recently PolyVivo PLGA MW ~100kDa 50:50 (currently AP089) was used to coat 3D magnesium implants by electrophoretic deposition thus improving their longevity.  Read more: Tian, Qiao Mu, and Hui Nan Liu. "Electrophoretic Deposition and Characterization of Biocomposites on Magnesium for Orthopedic Applications." In Advanced Materials Research, vol. 922, pp. 761-766. 2014. http://www.scientific.net/AMR.922.761.

“Abstract: The objective of this study is to produce a uniform and consistent nanophase hydroxyapatite (nHA) and poly (lactic-co-glycolic acid) (PLGA) coating on three-dimensional magnesium (Mg) implants using electrophoretic deposition (EPD) process. Mg is biodegradable, mechanically strong, and promising for orthopedic implant and device applications. However, currently available Mg and its alloys degrade too rapidly to meet clinical needs. To control Mg degradation and promote bone ingrowth, nHA/PLGA composite microspheres were synthesized and deposited onto Mg substrates using EPD process. Annealing was applied to improve the coating adhesion. The surface morphology, composition, and coating cross-section were examined using a scanning electron microscope and energy dispersive X-ray spectrometer. The results showed the presence of calcium, phosphorous, carbon, and oxygen peaks, indicating the successful deposition of nHA/PLGA microspheres on Mg. The corrosion resistance of the coated Mg was evaluated using the Tafel test. The results showed that the nHA/PLGA composite coating improved the corrosion resistance of Mg.”
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