PolySciTech (
www.polyscitech.com) provides a wide
variety of PLGA polymers. Recently these polymers have been utilized along with
porous silicon microspheres to create an intra-ocular delivery system for
daunorubicin delivery which reduces Proliferative vitreoretinopathy. Read
more: Nan, Kaihui, Feiyan Ma, Huiyuan
Hou, William R. Freeman, Michael J. Sailor, and Lingyun Cheng. "Porous
silicon oxide–PLGA composite microspheres for sustained ocular delivery of
daunorubicin." Acta biomaterialia (2014). http://www.sciencedirect.com/science/article/pii/S1742706114001937
“Abstract: A water-soluble anthracycline
antibiotic drug (daunorubicin, DNR) was loaded into oxidized porous silicon
(pSiO2) microparticles and then encapsulated with a layer of polymer (poly
lactide-co-glycolide, PLGA) to investigate their synergistic effects in control
of DNR release. Similarly fabricated PLGA–DNR microspheres without pSiO2, and
pSiO2 microparticles without PLGA were used as control particles. The composite
microparticles synthesized by a solid-in-oil-in-water emulsion method have mean
diameters of 52.33 ± 16.37 μm for PLGA–pSiO2_21/40–DNR and the mean diameter of
49.31 ± 8.87 μm for PLGA–pSiO2_6/20–DNR. The mean size, 26.00 ± 8 μm, of PLGA–DNR
was significantly smaller, compared with the other two (P < 0.0001). Optical
microscopy revealed that PLGA–pSiO2–DNR microspheres contained multiple pSiO2
particles. In vitro release experiments determined that control PLGA–DNR
microspheres completely released DNR within 38 days and control pSiO2–DNR
microparticles (with no PLGA coating) released DNR within 14 days, while the
PLGA–pSiO2–DNR microspheres released DNR for 74 days. Temporal release profiles
of DNR from PLGA–pSiO2 composite particles indicated that both PLGA and pSiO2
contribute to the sustained release of the payload. The PLGA–pSiO2 composite
displayed a more constant rate of DNR release than the pSiO2 control
formulation, and displayed a significantly slower release of DNR than either
the PLGA or pSiO2 formulations. We conclude that this system may be useful in
managing unwanted ocular proliferation when formulated with antiproliferation
compounds such as DNR. Keywords: Porous silicon oxide;
Poly(dl-lactide-co-glycolide); Daunorubicin; Ocular drug delivery”
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