Recently polymers from www.polyscitech.com (PolyVivo AK51 and PolyVivo AI75 for mPEG-PLGA
and Mal-PEG-PLGA respectively) were used to stabilize MFNCs generated as well
as conjugate the nanoparticles to thiolated neutravidin for binding assay. Read
more: Demillo, Violeta G., Mingxia Liao, Xiaoshan Zhu, Doug Redelman, Nelson G.
Publicover, and Kenneth W. Hunter. "Fabrication of MnFe< sub>
2
O< sub> 4-CuInS< sub> 2/ZnS
Magnetofluorescent Nanocomposites and Their Characterization." Colloids and Surfaces A:
Physicochemical and Engineering Aspects (2014).
http://www.sciencedirect.com/science/article/pii/S0927775714007870
“Abstract: Magnetofluorescent
nanocomposites (MFNCs) providing a single nanoscale platform with multimodal
properties are gaining momentum in biological manipulation, biomedical imaging
and therapies. In this work, we report the preparation of MFNCs integrating
MnFe2O4 magnetic nanoparticles (MNPs), CuInS2/ZnS quantum dots (QDs) and
poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PEG-PLGA) in a
tetrahydrofuran (THF)/water solvent system. Through sonication and quick
solvent displacement, multiple nanoparticles of each type are co-encapsulated
within the hydrophobic core of PEG-PLGA micelles. The developed fabrication
process is simple and fast. Moreover, due to the low toxicity of CuInS2/ZnS
QDs, the fabrication process is environmentally benign. The fabricated MFNCs
were further characterized regarding their fundamental physical, chemical and
biological properties. Results reveal that the MFNCs possess high (Mn + Fe)
recovery rates, and the optical properties and magnetic relaxivity of the MFNCs
are sensitive to the MNP:QD mass ratios in the fabrication. Furthermore, the
MFNCs present excellent stability in aqueous solutions, minimal cytotoxicity,
and capability for bioconjugation. This study opens an avenue for the MFNCs to
be employed in broad biological or biomedical applications. Keywords: Magnetofluorescent
nanocomposites; MnFe2O4 magnetic nanoparticles; CuInS2/ZnS quantum dots;
Poly(ethylene glycol)-b-poly(lactide-co-glycolide); Optical properties;
Magnetic relaxivity; Colloidal stability; Cytotoxicity; Bioconjugation”
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