PolySciTech (
www.polyscitech.com)
provides a wide array of PEG block copolymers and other specialty materials. One
of the materials provided by PolySciTech is PEG-PCL. Recently these types of
polymers were used as an oral delivery vehicle for docetaxel which may one day
hold promise for oral chemotherapy of breast cancer. Read more: Wang, YuJun,
LiJuan Chen, LiWei Tan, Qian Zhao, Feng Luo, YuQuan Wei, and ZhiYong Qian.
"PEG–PCL based micelle hydrogels as oral docetaxel delivery systems for
breast cancer therapy." Biomaterials (2014). http://www.sciencedirect.com/science/article/pii/S0142961214004979
“Abstract: In this study, a composite drug
delivery system was developed and evaluated for oral delivery of docetaxel:
docetaxel-loaded micelles in pH-responsive hydrogel (DTX-micelle–hydrogel).
Docetaxel was successfully loaded in micelles with small particle size of 20 nm
and high drug loading of 7.76%, which contributed to the drug absorption in the
intestinal tract. The experiments of cytotoxicity on 4T1 cells demonstrated the
effective antitumor activity of DTX micelles. Meanwhile, a pH-responsive
hydrogel was synthesized and optimized for incorporating the docetaxel
micelles. The pH-responsiveness and reversibility of the hydrogel were
investigated under the pH conditions of the gastrointestinal tract.
Furthermore, the DTX-micelle–hydrogel system showed much quicker diffusion of
micelles in simulated intestinal fluid than in simulated gastric fluid, which
was mainly caused by the change of pH value. The docetaxel released from the
micelle–hydrogel system quite slowly, so it had little influence on the
absorption of DTX micelles in small intestine. More important, the
pharmacokinetic study revealed that the DTX-micelle–hydrogel significantly
improved the oral bioavailability of docetaxel (75.6%) about 10 times compared
to DTX micelles, and this increase in bioavailability was probably due to the
small intestine targeting release of the pH-responsive hydrogel. Consequently,
the oral DTX-micelle–hydrogel system was effective in inhibiting tumor growth
in subcutaneous 4T1 breast cancer model, and decreased systemic toxicity
compared with intravenous treatment. The apoptosis cells in the
immunofluorescent studies and the proliferation-positive cells in the
immunohistochemical studies were also consistent with the results. Therefore,
the DTX-micelle–hydrogel system might be a promising candidate oral drug for
breast cancer therapy. Keywords: Docetaxel; Oral delivery; Micelles; Hydrogel;
Breast cancer”
No comments:
Post a Comment