Monday, January 5, 2015

PLGA nanoparticles for nervous system delivery

PolySciTech (www.polyscitech.com) provides a wide array of PLGA polymers. Recently these types of polymers were used to generate poly(arginine) labelled nanoparticles which were found to be effective at delivery of loperamide directly into the central nervous system with maximum anti-nociceptive effect. Read more: O'Donnell, Aisling, Azeema Moollan, Samantha Baneham, Melike Ozgul, Ritesh M. Pabari, Dermot Cox, Brian P. Kirby, and Zebunnissa Ramtoola. "Intranasal and intravenous administration of octaarginine modified poly (lacticcoglycolic acid) nanoparticles facilitates central nervous system delivery of loperamide." Journal of Pharmacy and Pharmacology (2015). http://onlinelibrary.wiley.com/doi/10.1111/jphp.12347/full

“Abstract: The potential of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) surface modified with octa-arginine (R8) for central nervous system (CNS) delivery was investigated. PLGA NPs containing coumarin-6 or loperamide were surface modified using R8 and characterised for size, zeta potential, drug loading and release. We examined the cellular uptake of NPs in Madin-Darby Canine Kidney (MDCK) cells and CNS delivery of loperamide in a mouse model following intranasal (i.n.) and intravenous (i.v.) administration. NPs were 300–350nm in diameter and of negative zeta potential which neutralised on R8 conjugation. Cellular uptake of R8-PLGA NPs was rapid compared with PLGA NPs and correlated with a high antinociceptive effect in mice by both the i.n. and i.v. routes. Little antinociceptive effect for PLGA NPs was observed reflecting their slow uptake in the in-vitro cell model. This study demonstrates the potential of R8-PLGA NPs as carriers of therapeutic agents to the CNS. Keywords: central nervous system delivery;loperamide;nanoparticles;octa-arginine;PLGA.”
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