Tuesday, January 20, 2015

PLGA-PEG-PLGA used to control release of protein from microparticles

PolySciTech (www.polyscitech.com) provides a wide array of block copolymers such as PLGA-PEG-PLGA triblock. Recently these polymers were formulated with PLGA and lysozyme to generate microparticles with modulated protein release. Read more: Qodratnama, Roozbeh, Lorenzo Pio Serino, Helen C. Cox, Omar Qutachi, and Lisa J. White. "Formulations for modulation of protein release from large-size PLGA microparticles for tissue engineering." Materials Science and Engineering: C 47 (2015): 230-236. http://www.sciencedirect.com/science/article/pii/S0928493114007048

“Abstract: In this study we present an approach to pre-program lysozyme release from large size (100–300 μm) poly(dl-lactic acid-co-glycolic acid) (PLGA) microparticles. This approach involved blending in-house synthesized triblock copolymers with a PLGA 85:15. In this work it is demonstrated that the lysozyme release rate and the total release are related to the mass of triblock copolymer present in polymer formulation. Two triblock copolymers (PLGA–PEG1500–PLGA and PLGA–PEG1000–PLGA) were synthesized and used in this study. In a like-for-like comparison, these two triblock copolymers appeared to have similar effects on the release of lysozyme. It was shown that blending resulted in the increase of the total lysozyme release and shortened the release period (70% release within 30 days). These results demonstrated that blending PLGA–PEG–PLGA triblock copolymer with PLGA 85:15 can be used as a method to pre-program protein release from microparticles. These microparticles with modulated protein release properties may be used to create microparticle-based tissue engineering constructs with pre-programmed release properties. Keywords: Triblock copolymer; Microparticle; Lysozyme; PLGA–PEG–PLGA; Controlled release; Glass transition temperature Highlights: Two triblock copolymers (PLGA–PEG1500–PLGA and PLGA–PEG1000–PLGA) were synthesized. Triblock copolymers have similar effects on the lysozyme release from PLGA microparticles. Triblock copolymers increased the total lysozyme release and shortened the release period. Increase in triblock copolymer mass was associated with higher release rate. Increase in triblock copolymer mass was associated with shorter release period.”
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