Monday, February 23, 2015

PEG-PLGA block copolymer optimized for nanoparticle preparation

PolySciTech (www.polyscitech.com) provides a wide array of mPEG-PLGA polymers. Recently these types of polymers were reported for use in an optimized nanoparticle emulsion method. Read more: Yoneki, Nao, Taku Takami, Tomoki Ito, Ryosuke Anzai, Kengo Fukuda, Keita Kinoshita, Seiichi Sonotaki, and Yoshihiko Murakami. "One-pot facile preparation of PEG-modified PLGA nanoparticles: Effects of PEG and PLGA on release properties of the particles." Colloids and Surfaces A: Physicochemical and Engineering Aspects (2015). http://www.sciencedirect.com/science/article/pii/S0927775715000291

“Abstract: We show here a one-pot facile preparation of poly(ethylene glycol) (PEG)-modified poly(lactide-co-glycolide) (PLGA) nanoparticles by means of a novel “block copolymer-assisted” emulsification/evaporation method. In the present article, we clarified the effects of preparation conditions and the structural properties of both polymeric modifiers and particle-forming hydrophobic polymers on the properties of the PEG-modified PLGA nanoparticles. We first clarified that the concentration of PLGA, the volume ratio of an organic solvent to a PVA solution, and a stirring rate were major factors affecting the diameter of the nanoparticles. We successfully prepared the nanoparticles, with a diameter of approximately 200 nm under the optimized conditions. The additive amount and the composition of PEG–PLA block copolymers affected the surface charge of the nanoparticles. Finally, we clarified that the compositions and molecular weights of the block copolymers greatly affected the release properties of PEG-modified nanoparticles. Keywords: Nanoparticle; Surface modification; Poly(ethylene glycol) (PEG); Poly(lactide-co-glycolide) (PLGA); Drug delivery system”


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