Monday, February 2, 2015

PolySciTech PS-P(DL)La copolymer used for nanoparticle anticancer docetaxel delivery

PolySciTech (www.polyscitech.com) provides a wide array of block copolymers. One of these polymers is polystyrene-b-poly(DL)Lactide (AK34).  Recently this polymer was used to develop a nanaoparticle delivery system for docetaxel to prostate cancer cells. Read more: Lee, Jae-Young, Jung Sun Kim, Hyun-Jong Cho, and Dae-Duk Kim. "Poly (styrene)-b-poly (DL-lactide) copolymer-based nanoparticles for anticancer drug delivery." International journal of nanomedicine 9 (2014): 2803. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051715/

“Abstract: Poly(styrene)-b-poly(DL-lactide) (PS-PDLLA) copolymer-based nanoparticles (NPs) of a narrow size distribution, negative zeta potential, and spherical shape were fabricated for the delivery of docetaxel (DCT). The particle size was consistently maintained in serum for 24 hours and a sustained drug release pattern was observed for 10 days in the tested formulations. The cytotoxicity of the developed blank NPs was negligible in prostate cancer (PC-3) cells. Cellular uptake and distribution of the constructed NPs containing a hydrophobic fluorescent dye was monitored by confocal laser scanning microscopy (CLSM) for 24 hours. Anti-tumor efficacy of the PS-PDLLA/DCT NPs in PC-3 cells was significantly more potent than that of the group treated with commercially available DCT, Taxotere®)." 
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