Thursday, March 12, 2015

PolySciTech PLA utilized for development of cell-borne drug delivery system

PolySciTech (www.polyscitech.com) provides a wide array of biodegradable polymers including PLA. Recent research has utilized PolySciTech PLA (PolyVivo AP071) for development of adhesive cell-plate which attaches to a live cell. Read more: Xia, Junfei, Zhibin Wang, Danting Huang, Yuanwei Yan, Yan Li, and Jingjiao Guan. "Asymmetric Biodegradable Microdevices for Cell-borne Drug Delivery." ACS Applied Materials & Interfaces (2015). http://pubs.acs.org/doi/abs/10.1021/acsami.5b00613

“Abstract: Use of live cells as carriers for drug-laden particulate structures possesses unique advantages for drug delivery. In this work, we report on the development of a novel type of particulate structures called microdevices for cell-borne drug delivery. The microdevices were fabricated by soft lithography with a disk-like shape. Each microdevice was composed a layer of biodegradable thermoplastic such as poly(lactic-co-glycolic acid). One face of the thermoplastic layer was covalently grafted with a cell-adhesive polyelectrolyte such as poly-L-lysine. This asymmetric structure allowed the microdevices to bind to live cells through bulk mixing without causing cell aggregation. Moreover, the cell-microdevice complexes were largely stable, and the viability and proliferation ability of the cells were not affected by the microdevices over a week. In addition, sustained release of a mock drug from the microdevices was demonstrated. This type of microdevices promises to be clinically useful for sustained intravascular drug delivery.”
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