Monday, May 18, 2015

PLGA-PEG-PLGA used for simvastatin delivery thermogel

PolySciTech (www.polyscitech.com) provides a wide array of PLGA-PEG-PLGA thermogel polymers used for a wide variety of research applications. Recently, researchers have utilized PLGA-PEG-PLGA thermogels for delivery of simvastatin for bone tissue regeneration. Read more: Yan, Qi, LiQun Xiao, Lei Tan, Wei Sun, Tao Wu, LiangWen Chen, Yan Mei, and Bin Shi. "Controlled release of simvastatinloaded thermosensitive PLGAPEGPLGA hydrogel for bone tissue regeneration: In vitro and in vivo characteristics." Journal of Biomedical Materials Research Part A (2015). http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.35499/abstract

“Abstract: Reports on the local delivery of drug loaded injectable hydrogels for bone regeneration are currently limited. This study assessed the effect of controlled simvastatin (SIM) release from a thermo-sensitive hydrogel in vitro and in vivo. We successfully manufactured and evaluated thermo-sensitive poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,L-lactide-co-glycolide) triblock copolymers (PLGA-PEG-PLGA) loaded with SIM. The osteogenic effect of this hydrogel was tested in vitro and in vivo. MC-3T3 E1 cells proliferation and osteoblastic differentiation were analyzed after cultivation with the hydrogel extracts. Cells co-cultured with SIM/PLGA-PEG-PLGA extracts showed an increase in mineralization and osteogenic gene expression compared to the other two groups. Additionally, the characteristics of this composite in vivo were demonstrated using a rat bone defect model. The bone defects injected with SIM/PLGA-PEG-PLGA hydrogel showed increased new bone formation compared to samples treated with PLGA-PEG-PLGA and control samples. The results of this study suggest that SIM/PLGA-PEG-PLGA might provide potential therapeutic value for bone healing. Keywords: PLGA-PEG-PLGA;simvastatin;drug delivery;thermo-sensitive;bone”
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