Thursday, May 7, 2015

Solubility of PLLA type polymers

PolySciTech ( provides a wide array of polymers of many different types. Often I receive questions about why PLLA and related PEG-PLLA lacks solubility in some organic solvents such as acetone or THF. This is due to chirality. The PLLA type polymers have relatively poor solubility in solvents such as THF and acetone because the PLLA polymer chains pack into crystaline domains that THF can not dissolve well. They do have good solubility in other solvents such as DCM. Conversely, P(DL)La type polymers have good solubility in acetone and THF as well as DCM. PST has a handy solubility chart for polymers here (
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