Thursday, May 7, 2015

Technical Note: AK097 Dissolution

PolySciTech (www.polyscitech.com) provides a wide array of PLGA-PEG-PLGA thermogels. Several of these thermogels (AK12 and AK24) have optimal dissolution in cold water (5-10C) due to a low LCST of about 20C. Recently, in-house testing has shown that PLGA-PEG-PLGA thermogels which have a higher LCST ~30C such as AK97 and some others dissolve best at room temperature and dissolve very slowly to not at all when in cold condition. For the use of AK097 thermogels in your lab dissolve at room temperature for a few days prior to injecting. For use of AK12/AK24 type thermogels dissolve in cold condition (5-10C).
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