Monday, June 8, 2015

PLGA nanoparticles in microgel for multistage drug delivery

PolySciTech (www.polyscitech.com) provides a wide array of PLGA polymers. Recently this type of polymer was used to generate a multi-stage drug delivery platform by incorporating the drug loaded PLGA nanoparticles inside of a PEG hydrogel. Read more: Hsu, Myat Noe, Rongcong Luo, Kerwin Zeming Kwek, Yong Chen Por, Yong Zhang, and Chia-Hung Chen. "Sustained release of hydrophobic drugs by the microfluidic assembly of multistage microgel/poly (lactic-co-glycolic acid) nanoparticle composites." Biomicrofluidics 9, no. 5 (2015): 052601. http://scitation.aip.org/content/aip/journal/bmf/9/5/10.1063/1.4916230.


“Abstract: The poor solubility of many newly discovered drugs has resulted in numerous challenges for the time-controlled release of therapeutics. In this study, an advanced drug delivery platform to encapsulate and deliver hydrophobic drugs, consisting of poly (lactic-co-glycolic acid) (PLGA) nanoparticles incorporated within poly (ethylene glycol) (PEG) microgels, was developed. PLGA nanoparticles were used as the hydrophobic drug carrier, while the PEG matrix functioned to slow down the drug release. Encapsulation of the hydrophobic agents was characterized by fluorescence detection of the hydrophobic dye Nile Red within the microgels. In addition, the microcomposites prepared via the droplet-based microfluidic technology showed size tunability and a monodisperse size distribution, along with improved release kinetics of the loaded cargo compared with bare PLGA nanoparticles. This composite system has potential as a universal delivery platform for a variety of hydrophobic molecules.”
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