Monday, June 1, 2015

PLGA-PEG-PLGA/montmorillonite system used for delivery of aspirin

PolySciTech (www.polyscitech.com) provides a wide array of PLGA-PEG-PLGA block copolymers. Recently these types of polymers were used to generate a system of microparticles and this was used for asparin delivery. Read more: Liu, Hsin-Jiant, Hawn-Chung Chu, Li-Huei Lin, and Shu-Yuan Hsu. "Preparation and Drug Release of Aspirin-Loaded PLGA-PEG-PLGA/Montmorillonite Microparticles." International Journal of Polymeric Materials and Polymeric Biomaterials 64, no. 1 (2015): 7-14. http://www.tandfonline.com/doi/abs/10.1080/00914037.2014.886238


“Abstract: A polymerization method was used to synthesize biodegradable poly(lactide-co-glycolide)/poly(ethyleneglycol)/poly(lactide-co-glycolide) (PLGA-PEG-PLGA) copolymers. These copolymers were then used to prepare microparticles for encapsulating drug (aspirin). The results of X-ray diffraction (XRD) analysis showed that the montmorillonite (MMT) can be converted into organic montmorillonite (o-MMT). Subsequently, the emulsion solvent evaporation method was used to separately prepare aspirin-loaded PLGA-PEG-PLGA and aspirin-loaded PLGA-PEG-PLGA/o-MMT microparticles. The results of scanning electron microscopy (SEM) showed that microparticle formation was related to the polyvinyl alcohol (PVA) concentration and the proportion of o-MMT. In addition, the ultraviolet-visible (UV-Vis) spectroscopy was conducted to determine the release rate of these microparticles.”
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