PolySciTech
division of Akina, Inc. (www.polyscitech.com)
provides a wide array of biodegradable block copolymers including mPEG-PLGA.
This polymer has a water-soluble side (mPEG) and an oil-soluble side (PLGA).
Because of this, it tends to self-assemble into micelles or particles that
disperse in water and contain oil-soluble compounds in the interior core.
Typically administering such compounds to a patient is very difficult because
they cannot be dissolved in isotonic saline for injection and they tend to be
removed rapidly from the blood stream by the kidneys and liver. Dispersing
these hydrophobic medicinal compounds inside the polymer core allows them to
have longer circulation times and higher therapeutic effect. Recently research
has shown that mPEG-PLGA can assist in the codelivery of SH-aspirin and
curcumin to improve their therapeutic efficacy against ovarian cancer. Read
more: Zhou, Lin, Xingmei Duan, Shi Zeng, Ke Men, Xueyan Zhang, Li Yang, and
Xiang Li. "Codelivery of SH-aspirin and curcumin by mPEG-PLGA
nanoparticles enhanced antitumor activity by inducing mitochondrial
apoptosis." International journal of nanomedicine 10 (2015): 5205.
Full-Text available from NIH: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547632/
“Abstract: Natural
product curcumin (Cur) and H2S-releasing prodrug SH-aspirin (SH-ASA) are
potential anticancer agents with diverse mechanisms, but their clinical
application prospects are restricted by hydrophobicity and limited efficiency.
In this work, we coencapsulated SH-ASA and Cur into methoxy poly(ethylene
glycol)-poly (lactide-coglycolide) (mPEG-PLGA) nanoparticles through a modified
oil-in-water single-emulsion solvent evaporation process. The prepared
SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles had a mean particle size of
122.3±6.8 nm and were monodispersed (polydispersity index =0.179±0.016) in
water, with high drug-loading capacity and stability. Intriguingly, by treating
with SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles, obvious synergistic
anticancer effects on ES-2 and SKOV3 human ovarian carcinoma cells were
observed in vitro, and activation of the mitochondrial apoptosis pathway was
indicated. Our results demonstrated that SH-ASA/Cur-coloaded mPEG-PLGA
nanoparticles could have potential clinical advantages for the treatment of
ovarian cancer. Keywords: drug delivery, cancer therapy, ovarian cancer,
synergistic effect”
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