Thursday, October 8, 2015

Two review articles discuss use of Flamma Fluor dyes for nanocrystal tracking in-vivo

PolySciTech division of Akina, Inc ( provides a wide array of research products including USA distribution of Flamma Fluor dyes produced from BioActs. Recently two review articles came out which discuss the use of drug nanocrystals for chemotherapeutic applications. These articles discuss hybrid nanocrystal applications in which Flamma Fluor dyes are incorporated into the drug nanocrystals in order to render them fluorescent in the near-IR region. The applications of such nanocrystals and the near-IR imaging towards theranostics is discussed. Read more: Lu, Yi, Yan Chen, Richard A. Gemeinhart, Wei Wu, and Tonglei Li. "Developing nanocrystals for cancer treatment." Nanomedicine 10, no. 16 (2015): 2537-2552. Full-Text:
 “Abstract: Nanocrystals are carrier-free solid drug particles that are sized in the nanometer range and have crystalline characteristics. Due to high drug loading (as high as 100%) – free of organic solvents or solubilizing chemicals – nanocrystals have become attractive in the field of drug delivery for cancer treatment. Top–down and bottom–up approaches have been developed for preparing anticancer nanocrystals. In this review, preparation methods and in vivo performance of anticancer nanocrystals are discussed first, followed by an introduction of hybrid nanocrystals in cancer theranostics.”
Also you can read about this application of these dyes in another review article here: Kaur, Veerpal, Tejinder Singh, Supandeep Singh Hallan Nidhi, and Neeraj Mishra. "Surface Modified Nanoparticulate Carriers for the Targeted Treatment of Breast Cancer."

“Abstract: Breast cancer left overs one of the greatest common metastasis disease in females. Advanced diagnostic devices and better understanding of tumour biology can extend the better therapeutic outcomes. Nanotechnology is a tool that helps in cancer diagnosis and treatment therapy. Many nanocarriers such as solid lipid nanoparticles, magnetic nanoparticles, nanocrystals, nanogels, nano-lipid nanocarriers, biodegradable nanoparticles, liposomes, and dendrimers are introduced to improve the therapeutic efficacy of antineoplastic agents. Surface modified target drug delivery system has the potential to increase the therapeutic effects and also reduce the cytotoxicity of breast cancer. Different approaches have been explored for treatment of breast cancer. This review describes the recent advances in the development of nanocarriers used for the targeted treatment of breast cancer. It also focuses on etiology, risk factor and conventional therapy of breast cancer. KEYWORDS: Breast Cancer; Nano-carriers; Tumor Targeting; Ligands; Receptor.”
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