PolySciTech
Division of Akina, Inc. (www.polyscitech.com)
provides many block polymers including methoxy-poly(ethylene
glycol)-poly(caprolactone) (mPEG-PCL). The methoxy serves as an inert blocking endcap,
the PEG chain serves as a hydrophilic, water-soluble polymer to stabilize
particles in aqeous solution and the PCL chain serves as a hydrophobic portion
that can interact with poorly-water soluble drugs. Because of these properties,
under the right conditions, this kind of polymer can self-assemble into
micelles or nanoparticles which have a hydrophobic core for carrying medicinal
molecules and hydrophilic PEG layer on the exterior to stabilize the particles
in aqueous solutions. Recently, this kind of polymer was used by researchers at
Jinan University to generate nano-carriers containing genistein, a
poorly-soluble isoflavone that performs as a potent antitumor medicine, to
improve the deliverability of this molecule. PolySciTech has recently launched
a new mPEG-PCL product, AK105 (mPEG-PCL 5000-8000Da), which can be used for
similar applications. Read more: Zhang, Tianpeng, Huan Wang, Yanghuan Ye,
Xingwang Zhang, and Baojian Wu. "Micellar emulsions composed of
mPEG-PCL/MCT as novel nano-carriers for systemic delivery of genistein: a
comparative study with micelles." International journal of nanomedicine 10
(2015): 6175. Full-Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598212/
Blog dedicated to answering technical questions in an open format relating to PolySciTech (A division of Akina, Inc.) products.
Wednesday, November 11, 2015
mPEG-PCL used for genistein delivery micelle formation
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