Tuesday, January 5, 2016

Genexol and Oncogel properties

I often receive questions about the MW properties of Genexol and Oncogel, different formulations which have undergone clinical trials. Genexol is an mPEG-PLA based formulation with block sizes of 2000Da mPEG and 1750Da PLA(1). The most similar Polyvivo product to this one would be AK069.

Oncogel is based off of Regel which is a PLGA-PEG-PLGA with overall molecular weight of 4200Da and a ratio of LA:GA of 3:1(1). The most similar PolyVivo product to this one would be AK091.

Learn more about these formulations in the review article: (1) Cho, Hyunah, Jieming Gao, and Glen S. Kwon. "PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol–gels for drug delivery." Journal of Controlled Release (2015). http://www.sciencedirect.com/science/article/pii/S0168365915302674

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