Monday, January 25, 2016

PLGA-PEG investigated for Chrysin delivery against gastric cancer

PolySciTech division of Akina, Inc. (www.polyscitech.com) provides a wide array of biodegradable block copolymers including PEG-PLGA. Chrysin is a hydrophobic flavonoid with potent anti-inflammatory and anti-oxidant properties. However, when taken orally by humans, it has negligible bioavailability due to extensive degradation. Recently, tests involving delivery of Chrysin using PEG-PLGA have shown that it has increased potency when delivered using this system which results in down-regulation of marker genes involved with gastric cancer. Read more: Mohammadian, Farideh, Yones Pilehvar-Soltanahmadi, Mohsen Mofarrah, Mehdi Dastani-Habashi, and Nosratollah Zarghami. "Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles." Artificial Cells, Nanomedicine, and Biotechnology (2016): 1-7. http://www.tandfonline.com/doi/abs/10.3109/21691401.2015.1129615

“Abstract: Chrysin were well-documented as having significant biological roles particularly cancer chemo-preventive activity. However, the poor water solubility of chrysin limited their bioavailability and biomedical applications. In this study, we encapsulate the chrysin into PLGA-PEG nanoparticles for local treatment. In regard to the amount of the drug load, IC50 was significant decreased in nanocapsulated chrysin in comparison with free chrysin. This was confirmed through decrease of miR-18a, miR-21, and miR-221 genes expression by real-time PCR. The results demonstrated that PLGA-PEG-chrysin complexes can be more effective than free chrysin. Therefore, PLGA-PEG can be a better nanocarrier for this kind of hydrophobic flavonoid.”
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