Wednesday, March 30, 2016

PolyVivo polymers and reactive intermediates investigated for delivery of magnetic nanoparticles and quantum dots as part of cancer theranostics

PolySciTech division of Akina, Inc. (www.polyscitech.com) provides a wide variety of block copolymers and reactive intermediates. Recently, two PolySciTech polymers PolyVivo AK051 (mPEG-PLGA 5000-5000Da) and PolyVivo AI075 (Maleimide-PEG-PLGA 5000-5000Da) were used to generate targeted nanoparticles as part of delivery system of quantum dots to tumor cells. This allows for the simultaneous therapy and diagnostic approaches to cancer, known as theranostics. Read more: Zhu, Xiaoshan. "Magnetofluorescent Nanocomposites Integrating Magnetic Nanoparticles and Near Infrared Quantum Dots for Tumor Cell Targeting." In Materials Science Forum, vol. 856. 2016. http://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=16629752&AN=113640126&h=JADHJX1brxin1jyiZ%2FBR%2Fosqe0jGI7nRrK4hC8EZHTOX7EqIuT6eiCX2nhW2jByFd4SNxUtKv60KWP4A62eZEw%3D%3D&crl=c


“Abstract: In this work, we report the preparation of MFNCs integrating MnFe2O4 magnetic nanoparticles (MNPs), near infrared CuInS2/ZnS quantum dots (QDs) and poly(ethylene glycol)-b- poly(lactide-co-glycolide) (PEG-PLGA) in a tetrahydrofuran (THF)/water solvent system. It is found that the MFNCs possess high (Mn + Fe) recovery rates, and the optical properties and magnetic relaxivity of the MFNCs are tunable according to the MNP:QD mass ratios. Furthermore, the MFNCs present excellent capability for tumor cell targeting once they are conjugated with bioprobes specific to tumor cells. This study opens an avenue for the MFNCs to be employed in broad biological or biomedical applications.”
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