Tuesday, April 12, 2016

PLGA from PolySciTech used as part of biodegradable magnesium-based cardiovascular stent development

PolySciTech division of Akina, Inc. (www.polyscitech.com) provides a wide array of biodegradable polymers including PLGA. Recently PLGA from PolySciTech was used by researchers as a control polymer for development of polymer coated resorbable magnesium stents. Read more: Gu, Xinzhu, Zhongwei Mao, Sang-Ho Ye, Youngmi Koo, Yeoheung Yun, Tiasha Tarannum, Vesselin Shanov, and William R. Wagner. "Biodegradable, Elastomeric Coatings with Controlled Anti-proliferative Agent Release for Magnesium-based Cardiovascular Stents." Colloids and Surfaces B: Biointerfaces (2016). http://www.sciencedirect.com/science/article/pii/S0927776516302570

“Abstract: Vascular stent design continues to evolve to further improve the efficacy and minimize the risks associated with these devices. Drug-eluting coatings have been widely adopted and, more recently, biodegradable stents have been the focus of extensive evaluation. In this report, biodegradable elastomeric polyurethanes were synthesized and applied as drug-eluting coatings for a relatively new class of degradable vascular stents based on Mg. The dynamic degradation behavior, hemocompatibility and drug release were investigated for poly(carbonate urethane) urea (PCUU) and poly(ester urethane) urea (PEUU) coated magnesium alloy (AZ31) stents. Poly(lactic-co-glycolic acid) (PLGA) coated and bare stents were employed as control groups. The PCUU coating effectively slowed the Mg alloy corrosion in dynamic degradation testing compared to PEUU-coated, PLGA-coated and bare Mg alloy stents. This was confirmed by electron microscopy, energy-dispersive x-ray spectroscopy and magnesium ion release experiments. PCUU-coating of AZ31 was also associated with significantly reduced platelet adhesion in acute blood contact testing. Rat vascular smooth muscle cell (rSMC) proliferation was successfully inhibited when paclitaxel was released from pre-loaded PCUU coatings. The corrosion retardation, low thrombogenicity, drug loading capacity, and high elasticity make PCUU an attractive option for drug eluting coating on biodegradable metallic cardiovascular stents. Keywords: Polymer coating; magnesium stents; drug eluting coating”
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