Tuesday, June 14, 2016

Fluorescently labeled PLGA from PolySciTech used as part of self-assembled PLGA microparticle system research

PolySciTech division of Akina, Inc. (www.polyscitech.com) provides a wide array of biodegradable polymers for research usage. This includes fluorescently conjugated polymers such as PLGA conjugated to flamma-fluor dyes. Recently, researchers used Fluorescent PolyVivo AV008 (PLGA-FPR648, reference named in paper as related material PLGA-CY5) for development of a self-assembled microparticle system. Read more: Yeredla, Nitish, Taisuke Kojima, Yi Yang, Shuichi Takayama, and Mathumai Kanapathipillai. "Aqueous Two Phase System Assisted Self-Assembled PLGA Microparticles." Scientific Reports 6 (2016): 27736. http://www.nature.com/articles/srep27736

“Abstract: Here, we produce poly(lactide-co-glycolide) (PLGA) based microparticles with varying morphologies, and temperature responsive properties utilizing a Pluronic F127/dextran aqueous two-phase system (ATPS) assisted self-assembly. The PLGA polymer, when emulsified in Pluronic F127/dextran ATPS, forms unique microparticle structures due to ATPS guided-self assembly. Depending on the PLGA concentration, the particles either formed a core-shell or a composite microparticle structure. The microparticles facilitate the simultaneous incorporation of both hydrophobic and hydrophilic molecules, due to their amphiphilic macromolecule composition. Further, due to the lower critical solution temperature (LCST) properties of Pluronic F127, the particles exhibit temperature responsiveness. The ATPS based microparticle formation demonstrated in this study, serves as a novel platform for PLGA/polymer based tunable micro/nano particle and polymersome development. The unique properties may be useful in applications such as theranostics, synthesis of complex structure particles, bioreaction/mineralization at the two-phase interface, and bioseparations.”
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