Tuesday, June 7, 2016

Review paper covers methods and applications for use of PLA in drug delivery particles

The PolySciTech division of Akina, Inc. (www.polyscitech.com) provides a wide array of biodegradable PLGA and related copolymers as research products for designing drug delivery systems. Recently a review article has been published detailing the use of PLA for forming micro and nanoparticles as well as its applicability toward a variety of biomedical applications. Read more: Lee, Byung Kook, Yeonhee Yun, and Kinam Park. "PLA Micro-and Nano-Particles." Advanced Drug Delivery Reviews (2016). http://www.sciencedirect.com/science/article/pii/S0169409X16301806

“Abstract: Poly(d,l-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are widely used as controlled drug delivery systems of therapeutic molecules, including proteins, genes, vaccines, and anticancer drugs. Even though PLA-based particles have challenges to overcome, such as low drug loading capacity, low encapsulation efficiency, and terminal sterilization, continuous innovations in particulate formulations will lead to development of clinically useful formulations. Keywords: PLA; Micro-particles; Nano-particles; Fabrication methods; Drug delivery system”

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