PolySciTech division of Akina, Inc. (www.polyscitech.com) provides a wide array of biodegradable block copolymers including mPEG-PCL. Arthritis is a highly prevalent immune disorder which leads to joint destruction. It can be treated with anti-inflammatory agents, such as dexamethasone (a steroidal anti-inflammatory), but systemic application of this drug can lead to side-effects. Injecting the drug locally into joints is problematic as more than one joint may be affected by arthritis. Recently, mPEG-PCL was utilized to generate dexamethasone micelles and injected into an arthritic rat model intravenously. As part of inflammatory process, the vasculature around inflamed tissue becomes very ‘leaky’ and allows for easy passage of nanoparticles into inflamed tissue. This process allowed for preferential uptake of the mPEG-PCL nanoparticles into the inflamed arthritic tissue where the dexamethasone served to reduce inflammation and tissue damage. This targeted delivery allows for treatment of multiple joints from one injection and prevents side effects. This research holds promise for improved arthritis treatment. Read more: Wang, Qin, Jiayu Jiang, Wenfei Chen, Hao Jiang, Zhirong Zhang, and Xun Sun. "Targeted delivery of low-dose dexamethasone using PCL–PEG micelles for effective treatment of rheumatoid arthritis." Journal of Controlled Release 230 (2016): 64-72. http://www.sciencedirect.com/science/article/pii/S0168365916301821.