Tuesday, October 18, 2016

PLGA from PolySciTech used as part of antimicrobial bioadhesive development

PolySciTech division of Akina, Inc. (www.polyscitech.com) provides a wide array of biodegradable polymers including PLGA. Recently, researchers working on development of novel bioadhesives used PLGA from PolySciTech (Cat# AP154) as a control for standardizing their cytotoxicity assay. This research holds promise for development of novel wound-closure technologies such as bioadhesives which can be used to ‘glue’ wounds shut, in a biocompatible matter, so as to reduce the need for staples and sutures. Read more: Guo, Jinshan, Gloria B. Kim, Dingying Shan, Jimin P. Kim, Jianqing Hu, Wei Wang, Fawzi G. Hamad, Guoying Qian, Elias B. Rizk, and Jian Yang. "Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives." Biomaterials (2016). http://www.sciencedirect.com/science/article/pii/S014296121630552X

“Abstract: For the first time, a convenient copper-catalyzed azide-alkyne cycloaddition (CuAAC, click chemistry) was successfully introduced into injectable citrate-based mussel-inspired bioadhesives (iCMBAs, iCs) to improve both cohesive and wet adhesive strengths and elongate the degradation time, providing numerous advantages in surgical applications. The major challenge to developing such an adhesive was the mutual inhibition effect between the oxidant used for crosslinking catechol groups and the Cu(II) reductant used for CuAAC, which was successfully minimized by adding a biocompatible buffering agent typically used in cell culture, 4-(2-hydroxyethyl) -1-piperazineethanesulfonic acid (HEPES), as a copper chelating agent. Among the investigated formulations, the highest adhesion strength achieved (223.11 ± 15.94 kPa) was around 13 times higher than that of a commercially available fibrin glue (15.4 ± 2.8 kPa). In addition, dual-crosslinked (i.e. click crosslinking and mussel-inspired crosslinking) iCMBAs still preserved considerable antibacterial and antifungal capabilities that are beneficial for the bioadhesives used as hemostatic adhesives or sealants for wound management. Keywords: Click chemistry; Bioadhesives; Mussel; Citric acid; Antimicrobial”
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