Thursday, March 22, 2018

PLGA from PolySciTech used in development of tannin-inspired antimicrobial bio-adhesives



A valuable tool for wound-healing and surgical procedures is tissue adhesives which can bind tissues together and allow them to regrow. Due to the potential for infection, it is desirable for these adhesives to have antibiotic properties. Recently, researchers at Pennsylvania State University, Zhejiang Wanli University, Harbin Engineering University, and Jiangxi Provincial Children’s Hospital used PLGA (PolyVivo AP154) from PolySciTech (www.polyscitech.com) to act as a biocompatibility control for testing the cytotoxicity of their developed systems. This research holds promise to improve would healing and prevent infections. Read more: Guo, Jinshan, Wei Sun, Jimin Peter Kim, Xili Lu, Qiyao Li, Min Lin, Oliver Mrowczynski et al. "Development of tannin-inspired antimicrobial bioadhesives." Acta Biomaterialia (2018). https://www.sciencedirect.com/science/article/pii/S1742706118301284

“Abstract: Tissue adhesives play an important role in surgery to close wounds, seal tissues, and stop bleeding, but existing adhesives are costly, cytotoxic, or bond weakly to tissue. Inspired by the water-resistant adhesion of plant-derived tannins, we herein report a new family of bioadhesives derived from a facile, one-step Michael addition of tannic acid and gelatin under oxidizing conditions and crosslinked by silver nitrate. The oxidized polyphenol groups of tannic acid enable wet tissue adhesion through catecholamine-like chemistry, while both tannic acid and silver nanoparticles reduced from silver nitrate provide antimicrobial sources inherent within the polymeric network. These tannin-inspired gelatin bioadhesives are low-cost and readily scalable and eliminate the concerns of potential neurological effect brought by mussel-inspired strategy due to the inclusion of dopamine; variations in gelatin source (fish, bovine, or porcine) and monomer feeding ratios resulted in tunable gelation times (36 s to 8 min), controllable degradation (up to 100% degradation within a month), considerable wet tissue adhesion strengths (up to 3.7 times to that of fibrin glue), excellent cytocompatibility, as well as antibacterial and antifungal properties. The innate properties of tannic acid as a natural phenolic crosslinker, molecular glue, and antimicrobial agent warrant a unique and significant approach to bioadhesive design. Keywords: tannin; polyphenol; gelatin; bioadhesives; antimicrobial; medical device”

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