Tuesday, December 11, 2018

Amine-PEG-PLGA from PolySciTech used in development of antibiotic formulation against food-borne illness

Although often overlooked, the impact of foodborne illness on society is not trivial. The CDC estimates 48 million are afflicted with 128K hospitalizations and roughly 3000 deaths from foodborne illness each year in USA (https://www.cdc.gov/foodborneburden/index.html). Rosin acids (from conifer trees) are a class of compounds which have good efficacy against a wide range of bacteria, but suffer from poor solubility and side-effects that limits their clinical usefulness. Recently, researchers at the Instituo de Investigacao e Inovacao, em Saude (Portugal) and the Institute of Sciences of Food Production, National Research Council (Italy) used amine-PEG-PLGA (AI058) from PolySciTech (www.polyscitech.com) to create rosin-acid bound nanoparticles and assayed these particles for their efficacy against bacteria. This research holds promise to improve therapies against foodborne illness including antibiotic resistant strains. Read more: Santovito, Elisa, José das Neves, Donato Greco, Vito D’Ascanio, Bruno Sarmento, Antonio Francesco Logrieco, and Giuseppina Avantaggiato. "Antimicrobial properties of rosin acids-loaded nanoparticles against antibiotic-sensitive and antibiotic-resistant foodborne pathogens." Artificial Cells, Nanomedicine, and Biotechnology (2018): 1-9. https://www.tandfonline.com/doi/abs/10.1080/21691401.2018.1496924

“Abstract: Rosin acids (RA) from coniferous trees are used in folk medicine for healing various skin infections. Despite the antimicrobial potential of RA, their poor solubility in aqueous media may limit their use. In this work RA-loaded polyethylene glycol-poly(lactic-co-glycolic acid) nanoparticles (RA-NPs) with enhanced antimicrobial properties against foodborne bacterial pathogens were produced. RA-NPs were prepared by solvent displacement technique and characterized for relevant colloidal features by dynamic light scattering, laser Doppler anemometry and transmission electron microscopy. Association of RA to NPs occurred with high yields (86% w/w). RA and RA-NPs (∼130 nm) were strongly active against antibiotic-sensitive Gram + pathogens, i.e. Clostridium perfringens, Listeria monocytogenes and antibiotic-resistant Staphylococcus aureus. However, both failed in inhibiting the growth of Gram – pathogens (Campylobacter jejuni, Campylobacter coli, Escherichia coli and Salmonella enterica). Association to NPs enhanced the antimicrobial activity of RA. MIC, IC50, IC90, and MBC values of RA-NPs were ten-times lower than RA. RA-NPs did not change the intrinsic toxicity potential of RA. This is the first study on the enhancement of the antimicrobial activity of RA when associated to nanocarriers. This approach may be an effective strategy to produce aqueous-based RA solutions with enhanced antimicrobial activity against antibiotic-sensitive and antibiotic-resistant Gram + pathogens. Keywords: Nanoparticles, antimicrobials, rosinic acids, pathogenic bacteria, nanocarriers”

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