Wednesday, February 6, 2019

Bezwada Biomedical Brand Polymers, on sale now at PolySciTech, used in research on improving shelf-life of food

In addition to providing in-house manufactured products, PolySciTech ( also provides for distribution of products from high-quality research vendors, especially those who provide ‘hard-to-find’ and unique materials relevant to the biomedical field. A massive sale is going on now for Bezwada-Brand polymers including both Poly(ethylene glycol) di(meth)acrylate(s) (AEB001-AEB007) and polyesters including PCL’s, PLCL’s, PGACL’s, PDO’s, PLA’s, PTMCLA’s, PLGA’s, PDOLA’s, PTMC’s, and PDOGALA’s (APB001-APB038). For online purchasing, use coupon-code BEZWADA40 to receive an additional 40% discount at checkout for these polymers.

Recently, these polymers were used by researchers at the Indian Institute of Technology for research in food-preservation technology to provide for extended release of antioxidants and antibiotics to food. This research holds promise to improve the food supply by reducing spoilage. Read more: Biswal, Agni Kumar, and Sampa Saha. "Prolonging food shelf-life by dual actives release from multi-layered polymer particles." Colloids and Surfaces B: Biointerfaces 175 (2019): 281-290.

“Highlights: Multilayered particles with antioxidant and antibacterial actives were fabricated in one step. Mechanism of tri-layered formation by using 2 polymers of varying viscosity was explained. Long term antibacterial and antioxidant activity were achieved from multi-layered particles. Abstract: Biodegradable polymer based 'controlled release packaging' technology has ability to release packaging actives in controlled manner to prolong the food shelf-life. Currently available systems are not sufficiently capable of releasing multiple actives in sustainable fashion. Hence, the purpose of this study was to develop dual actives (antioxidant and antibacterial) loaded multilayered microparticles in one step and to release them at rates suitable for long-term inhibition of bacterial growth as well as lipid oxidation in food. In order to achieve this goal, 2 kinds of multilayered polymer particles made up of PLLA (Poly(l-lactic acid)) and PLGA (Poly(dl-lactic-co-glycolic acid) with varying viscosity were developed using emulsion solvent evaporation method. Surprisingly, low viscous PLGA resulted tri-layered particles (PLGA/PLLA/PLGA: shell/middle/core) instead of bi-layered (PLGA/PLLA: shell/core) particles as observed for high viscous PLGA. The mechanism of formation of tri-layered particles was investigated in detail. The outermost layer consisted of relatively more hydrophilic polymer PLGA along with benzoic acid (antibacterial) and the inner core comprised of hydrophobic polymer PLLA and tocopherol (antioxidant). Release study demonstrated that release rate of dual actives were significantly accelerated from tri-layered particles in comparison to bi-layered one and their release profiles can be well explained with the help of Ridger-Peppas model. Both sets of particles exhibited long-term antibacterial (against both Escherichia coli and Staphylococcus aureus) as well as antioxidant effect over a period of 60 days. The results show for the first time the feasibility of using multilayered microparticles to prolong the food shelf-life by simultaneous release of multiple actives. Keywords: Multi-layer Biodegradable Polymer particles Controlled release Active packaging”

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