PLGA from PolySciTech used in development of 3D printed antibiotic scaffold

 

Any time the skin is punctured the potential for bacterial infiltration exists and can lead to localized infection. Recently, researchers at University of Prince Edward Island and Regis and Joan Duffy Research Centre (Canada) Used PLGA (AP036, AP149, AP020) From PolySciTech (www.polyscitech.com) to create a scaffold that releases antibiotics from a piercing to reduce the potential for infection. This research holds promise to prevent piercing-related infections. Read more: Naseri, Emad, Christopher Cartmell, Matthew Saab, Russell G. Kerr, and Ali Ahmadi. "Development of 3D Printed Drug-Eluting Scaffolds for Preventing Piercing Infection." Pharmaceutics 12, no. 9 (2020): 901. https://www.mdpi.com/1999-4923/12/9/901

“Abstract: Herein, novel drug-eluting, bio-absorbable scaffold intended to cover piercing studs is introduced. This “biopierce” will stay in human tissue following piercing, and will slowly release an antimicrobial agent to prevent infection while the wound heals. Nearly 20% of all piercings lead to local infection. Therefore, it is imperative to develop alternative methods of piercing aftercare to prevent infection. Biopierces were made using mupirocin loaded poly-lactic-co-glycolic acid (PLGA) biomaterial ink, and a low-temperature 3D printing technique was used to fabricate the biopierces. Proton nuclear magnetic resonance (1H NMR) spectroscopy was used to confirm the complete removal of the solvent, and liquid chromatography high-resolution mass spectrometry (LC-HRMS) was used to confirm the structural integrity of mupirocin and to quantify the amount of the released drug over time. The efficacy of the biopierces against Staphylococcus aureus, one of the most common piercing-site pathogens, was confirmed over two weeks using in vitro antimicrobial susceptibility testing. Keywords: biopierce; 3D printing; PLGA; bacterial test; drug eluting scaffolds”