mPEG-PLGA from PolySciTech used in development of microfluidic nanoparticles for delivery of peptides

 

Peptides represents an important and useful class of drugs which are limited due to their rapid breakdown in the blood stream. Recently researchers from The University of Queensland, National Center for Nanoscience and Technology, and Southern University of Science and Technology (China), mPEG-PLGA (Cat# AK026) from PolySciTech (www.polyscitech.com) was used for peptide delivery. This research holds promise to improve the longevity of peptide drugs thus extending their usefulness. Read More: Han, Felicity Y., Weizhi Xu, Vinod Kumar, Cedric S. Cui, Xaria Li, Xingyu Jiang, Trent M. Woodruff, Andrew K. Whittaker, and Maree T. Smith. "Optimisation of a Microfluidic Method for the Delivery of a Small Peptide." Pharmaceutics 13, no. 9 (2021): 1505. https://www.mdpi.com/1276894

“Abstract: Peptides hold promise as therapeutics, as they have high bioactivity and specificity, good aqueous solubility, and low toxicity. However, they typically suffer from short circulation half-lives in the body. To address this issue, here, we have developed a method for encapsulation of an innate-immune targeted hexapeptide into nanoparticles using safe non-toxic FDA-approved materials. Peptide-loaded nanoparticles were formulated using a two-stage microfluidic chip. Microfluidic-related factors (i.e., flow rate, organic solvent, theoretical drug loading, PLGA type, and concentration) that may potentially influence the nanoparticle properties were systematically investigated using dynamic light scattering and transmission electron microscopy. The pharmacokinetic (PK) profile and biodistribution of the optimised nanoparticles were assessed in mice. Peptide-loaded lipid shell-PLGA core nanoparticles with designated size (~400 nm) and a sustained in vitro release profile were further characterized in vivo. In the form of nanoparticles, the elimination half-life of the encapsulated peptide was extended significantly compared with the peptide alone and resulted in a much higher distribution into the lung. These novel nanoparticles with lipid shells have considerable potential for increasing the circulation half-life and improving the biodistribution of therapeutic peptides to improve their clinical utility, including peptides aimed at treating lung-related diseases. Keywords: drug delivery system; nanoparticles; poly (lactic-co-glycolic acid) (PLGA); microfluidic; pharmacokinetics (PK) and biodistribution”