PLGA from PolySciTech used in development of bioinspired surgical glue

 

A common problem in surgical applications is sealing tissues together which are separated either due to an incision or due to patient trauma. Although sutures and staples can be used to mechanically hold tissue together there are certain locations and applications where the physical constraints are too tight, the tissue is too weak, or these mechanical methods are inappropriate for other reasons. Any glue utilized for this application must possess biocompatibility, biodegradability, and the ability to seal to wet, biological surfaces. Recently, researchers at University of Texas at Arlington and University of Texas Southwestern Medical Center used PLGA (cat# AP036) from PolySciTech (www.polyscitech.com) to test a variety of nanocomposite adhesion strength. This research holds promise to provide for improved surgical techniques in the future. Read more: Pandey, Nikhil, Luis Soto-Garcia, Serkan Yaman, Aneetta Kuriakose, Andres Urias Rivera, Valinda Jones, Jun Liao, Philippe Zimmern, Kytai T. Nguyen, and Yi Hong. "Polydopamine nanoparticles and hyaluronic acid hydrogels for mussel-inspired tissue adhesive nanocomposites." Materials Science and Engineering: C (2021): 112589. https://www.sciencedirect.com/science/article/pii/S0928493121007293

“Highlights: Mussel-inspired hydrogels are promising for tissue attachment under wet conditions. Nanoparticles addition can enhance the adhesive strength of a hydrogel adhesive. Polydopamine nanoparticles and catechol-modified hyaluronic acid are combined. The nanocomposite showed improved adhesive strength and good cytocompatibility. The adhesive has opportunities to be utilized as a tissue glue for biomedicine. Abstract: Bioadhesives are intended to facilitate the fast and efficient reconnection of tissues to restore their functionality after surgery or injury. The use of mussel-inspired hydrogel systems containing pendant catechol moieties is promising for tissue attachment under wet conditions. However, the adhesion strength is not yet ideal. One way to overcome these limitations is to add polymeric nanoparticles to create nanocomposites with improved adhesion characteristics. To further enhance adhesiveness, polydopamine nanoparticles with controlled size prepared using an optimized process, were combined with a mussel-inspired hyaluronic acid (HA) hydrogel to form a nanocomposite. The effects of sizes and concentrations of polydopamine nanoparticles on the adhesive profiles of mussel-inspired HA hydrogels were investigated. Results show that the inclusion of polydopamine nanoparticles in nanocomposites increased adhesion strength, as compared to the addition of poly (lactic-co-glycolic acid) (PLGA), and PLGA-(N-hydroxysuccinimide) (PLGA-NHS) nanoparticles. A nanocomposite with demonstrated cytocompatibility and an optimal lap shear strength (47 ± 3 kPa) was achieved by combining polydopamine nanoparticles of 200 nm (12.5% w/v) with a HA hydrogel (40% w/v). This nanocomposite adhesive suggests its potential as a tissue glue for biomedical applications.”