PLGA from PolySciTech used in development of wound-healing antibiotic delivery system

 

Wounds often heal poorly due to bacterial intrusion. Recently, researchers at Assiut University (Egypt) utilized PLGA from PolySciTech (www.polyscitech.com) to create silk-PLGA nanoparticles to improve wound healing. This research holds promise to improve treatments against infected wounds. Read more: Abd El-Aziz, Fatma El-Zahraa A., Helal F. Hetta, Basma N. Abdelhamid, and Noura H. Abd Ellah. "Antibacterial and wound-healing potential of PLGA/spidroin nanoparticles: a study on earthworms as a human skin model." Nanomedicine 0 (2022). https://www.futuremedicine.com/doi/abs/10.2217/nnm-2021-0325

“Aim: The essential protein element of spider silk ‘spidroin’ was used to assess its impact on the wound-healing process. Methods: Spidroin nanoparticles (NPs) were prepared using poly(lactic-co-glycolic acid) polymer (PLGA/spidroin NPs) at different weight ratios (5:1, 10:1, 15:1) and were in vitro characterized. The optimized NPs were tested in vitro for release and antibacterial activity. To assess wound-healing effects, NPs were topically applied on surgically induced injuries in Allolobophora caliginosa earthworms as a robust human skin model. Results: Optimized NPs (173 ± 3 nm) revealed considerable antibacterial effect against Staphylococcus aureus and Escherichia coli. After 4 days of NPs application on wounds, macroscopical and histological examinations revealed a significant reduction in wound and re-epithelialization times. Conclusion: PLGA/spidroin NPs may represent a promising option for wound repair.”