PLA from PolySciTech used in development of treatment of gastroschisis

 

Reported gastroschisis has increased over the past 25 years from 0.1 cases per 10,000 to 1 case per 10,000 live births in developed countries, and from 3 to 5 cases per 10,000 births in developing countries. Recently, researchers from Universitas Airlangga (Indonesia) utilized PLLA (cat# AP006) from PolySciTech division of Akina (www.polyscitech.com) to develop spring-loaded drug delivery systems for treatment of gastroschisis. This research holds promise to improve treatments against this birth defect. Read more: Widiyanti, Prihartini, Fahreza Rachmat Yoviansyah, and Djony Izak Rudyarjo. "Poly L-Lactic Acid (Plla)-Collagen Coating Chitosan as a Spring-Loaded Silo Candidate for Gastroschisis." Journal of International Dental and Medical Research 15, no. 2 (2022): 950-955. http://www.jidmr.com/journal/wp-content/uploads/2022/06/77-MD22_1740_Prihartini_Widiyanti_Indonesia.pdf

“Abstract: Gastroschisis is one of the birth defects with organ conditions that come out of the abdominal cavity. The handling of gastroschisis is conducted by the staged closure method or wrapping the organ that comes out to be inserted slowly using gravity and a spring-loaded silo. To overcome this problem, a research study was conducted to find candidates for spring loaded silos with the combination of 5% PLLA, collagen with various concentrations (1, 0.75, 0.5, and 0.25)%, and 1% chitosan which was expected to reduce the risk of side effects in infants with gastroschisis such as infections and microbes. It can also improve the mechanical properties of the spring-loaded silo membrane. Based on the FTIR test, it showed the functional groups of PLLA (Ester), Collagen (Amide), and Chitosan (Amine). The SEM results showed that the overall pore value was 4.42-6.67 µm, thus it can meet the goretex pore size with a pore size range of 0-25 µm. The results of the tensile strength test, the UTS value on the abdominal wall was 2 - 9.2 MPa, thus the K2 sample with a value of 8.56 MPa has met and the value of the Elasticity Modulus of the linear alba layer on the abdominal wall was 23 - 335 MPa. The results of the contact angle test showed that the PLLA-Collagen chitosan coating samples were better on hydrophilic properties than the PLLA-Collagen samples. Cytotoxicity test results showed that the percentage of living cells was above 70% thus the membrane was non-toxic.”