mPEG-PLA from PolySciTech used in development of ultrasound triggered nanocarrier particles

 

Targeted drug delivery in a living body can be achieved by applying a non-invasive ‘trigger’ which creates a change in the delivery carrier that releases the medicinal compound from the system. This can be done by using low intensity ultrasound which can cause nanoparticles to release their payload of medicine at the location where the ultrasound is focused. Researchers at University of Utah used mPEG-PLA (Cat# AK009) from PolySciTech Division of Akina, Inc. (www.polyscitech.com) to create nanoparticles that can be triggered by ultrasound to release on demand. This research holds promise to provide for controlled, localized drug delivery. Read more: Wilson, Matthew G., Aarav Parikh, and Jan Kubanek. "Effective ultrasound-triggered drug release from stable nanocarriers." bioRxiv (2022): 2021-12. https://www.biorxiv.org/content/10.1101/2021.12.14.471689.abstract

“Abstract: Selective delivery of concentrated medication into specified targets would realize the promise of effective personalized medicine with minimal side effects. Low-intensity ultrasound provides noninvasive and practical means to deliver drugs from nanocarriers selectively into its focus. However, which nanocarriers and ultrasound parameters can provide effective and safe drug delivery has been unclear. We found that nanocarriers with highly stable perfluorocarbon cores mediate effective release so long as they are activated by ultrasound of relatively low frequencies. We further demonstrated a repeatable method for manufacturing these nanocarriers to help facilitate future work in this area. This study guides the formulation and release parameters for effective and safe drug delivery into specific parts of the body or brain regions.”

See Video: https://youtu.be/8G2X1pIc2sg