PLLA from PolySciTech used in development of PLA-Chitosan electrospun mesh for tissue engineering

 

As a means to prevent stroke, Carotid Endarterectomy is commonly performed to improve the vessel condition for transporting blood to the brain. However, there is significant risk with this procedure of the vessel reclosing or other complications. A better option is to utilize a scaffold which will allow for the growth of a wider vessel to repair or replace the damaged one. Recently, researchers at Universitas Airlangga (Indonesia) used PLLA (Cat# AP006) from PolySciTech division of Akina, Inc. (www.polyscitech.com) to create a composite mesh for vessel repair. This research holds promise to improve treatment of vascular diseases. Read More: Salsabila, Dhea Saphira, Prihartini Widiyanti, Edric Hernando, Indira Maretta Hulu, and Tarissa Diandra Putri Wibowo. "Characterization of Coaxially Electrospun Poly (L-Lactic) Acid/Chitosan with Heparin Modification as Patch Angioplasty Candidate." Journal of Membrane Science and Research 9, no. 1 (2023). http://www.msrjournal.com/&url=http:/www.msrjournal.com/article_699986.html

“Atherosclerosis in the carotid artery is the leading cause of ischemic stroke. Carotid Endarterectomy (CEA) is a procedure of atherosclerosis plaque removal to prevent stenosis, which significantly reduces the risk of transient ischemic attack. Currently, the application of commercialized patch grafts in CEA has shown several disadvantages regarding its incompatibility with the carotid artery. Poly (L-Lactic) Acid (PLLA)/Chitosan (CS) electrospun fibers with heparin modification were fabricated as biocompatible patch graft through coaxial electrospinning with composition variations of 1:0; 1:2; 1:3; 1:4. Pre-synthesis measurement of viscosity and surface tension was conducted to optimize the electrospinnability of PLLA 10% and CS 3% (w/v). FTIR results confirmed the existence of each material's functional group. Physical and mechanical properties were enhanced along with the increased PLLA/CS ratio. The hydrophilicity was optimized by the 1:4 electrospun fibers, which reduced the contact angle to 27°. The 1:4 electrospun fibers also resulted in a suitable degradation rate within 72 days and desirable tensile strength at 3.864 with 24.8% elongation. According to the results, Poly (L-Lactic) Acid/Chitosan electrospun fibers have a promising potential as a patch angioplasty candidate”

Video: https://youtu.be/i9SY5aS8x10