PLGA-PEG-PLGA from PolySciTech used in development of topical cream for skin-cancer treatment

 

Melanoma is a form of skin cancer which can be treated in early stages by localized delivery of chemotherapy agents to the skin. Researchers at St. John’s University and OncoGone, Inc. used thermogelling PLGA-PEG-PLGA (AK012 and AK019) from PolySciTech division of Akina, Inc. (www.polyscitech.com) to create thermally sensitive nanogels for delivery of paclitaxel (PTX) and temozolomide (TMZ) as melanoma treatment. This research holds promise to improve therapy against skin cancer. Read more: Rahman, Sadia, Tasmima N. Haque, Vrashabh V. Sugandhi, Aishwarya L. Saraswat, Xiaoban Xin, and Hyunah Cho. "Topical Cream Carrying Drug-Loaded Nanogels for Melanoma Treatment." Pharmaceutical Research (2023): 1-11. https://link.springer.com/article/10.1007/s11095-023-03506-z

“Abstract: In this study, nanogel creams carrying paclitaxel (PTX) and temozolomide (TMZ) were prepared for the topical treatment of melanoma. PTX and TMZ were first loaded in poly-(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly-(D,L-lactide-co-glycolide) (PLAG-b-PEG-b-PLGA) thermosensitive nanogels, which made a transition from a free-flowing sol (formation of micellar network) at 25°C with the z-average particle size of c.a. 96 nm to a gel (aggregation of micelles) at 33°C with the z-average particle size of c.a. 427 nm. An anhydrous absorption ointment base, aquaphor, was then added to drug-loaded nanogels to form nanogel creams carrying PTX and TMZ. Nanogel creams permitted controlled release of the payloads and improved the penetration of the payloads through the rodent skin compared to drug(s)-loaded nanogels. PTX and TMZ in a combination were synergistically effective in inhibiting SK-MEL28, A375, and B16-F10 melanoma cancer cells in vitro. Topically applied nanogel creams carrying TMZ/PTX (4 mg/1.5 mg/dose) showed a trend of tumor volume inhibition on B16-F10-bearing xenograft mice in vivo.”

Video: https://youtu.be/m3YxnU8SGnk

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