PLGA from PolySciTech used in research on bone-scaffold for tissue repair.

 

A powerful wound-healing technique is to implant a cell scaffold which provides a surface for the patient’s own cells to heal missing or damaged tissue. Researchers at Universitas Brawijaya (Indonesia) used PLGA (cat# AP082) from PolySciTech division of Akina, Inc. (www.polyscitech.com) as part of development of a hydroxyapatite/PVA/PLGA bone scaffold. This research holds promise to provide for healing of bone lost due to disease or trauma. Read more: Istikharoh, Feni, Lalita El Milla, and Ericka Fairuz Ramadhani. "The Effect of the Addition of Poly Lactic co glycolic acid on the Porosity Of Nanoparticle Hydroxyapatite-Polyvinyl Alcohol Scaffold as Candidate Bonegraft Material." E-Prodenta Journal of Dentistry 7, no. 1 (2023): 717-724. https://eprodenta.ub.ac.id/index.php/eprodenta/article/view/202

“Background: Bone loss has a major impact on the process of placing implants and dentures. Nanoparticle hydroxyapatite (HANP) has better biodegradability and mechanical properties than micro-particle hydroxyapatite. PVA is a synthetic polymer that is cheap, hydrophilic, has high mechanical stability and flexibility but low biodegradability. PLGA is a new synthetic polymer which is widely used in the biomedical, however PLGA has less osteoconductive properties. The ideal scaffold has several important characteristics, one of which is having a porosity of>70%. Objective: To know the role of PLGA on the porosity of the scaffold by comparing the porosity of the HANP-PVA scaffold and the HANP-PVA scaffold given PLGA Methods: Group 1 was the HANP-PVA scaffold with a content of 20% HANP (w / w). Group 2 was the HANP-PVA scaffold which added 20% (w/w) of PLGA. Both groups were synthesized by freeze drying method at -80oC for 24 hours. The porosity test was used the liquid displacement method for 24 hours. Statistical testing using Shapiro Wilk, Levene's test and Independent t-Test Results: The porosity of the HANP-PVA scaffold was 77.90% ± 4.51 and the HANP-PVA-PLGA scaffold was 87.55% ± 5.67. The Shapiro-Wilk normality test showed that the data were normally distributed (p> 0.05). The independent t test showed a significant difference between the HANP-PVA and HANP-PVA-PLGA scaffold (p <0.05) Conclusions: The addition of PLGA to the scaffold can increase the porosity of the HANP-PVA scaffold. HANP-PVA-PLGA has the potential to accelerate bone regeneration after extraction. Keyword: bone loss, PVA, PLGA, Hydroxyapatite nanoparticle”