PLGA-Rhodamine from PolySciTech used in research on magnetic nanoparticles for magnetic-based cellular targeting.

 

One way to deliver drugs to the desired location in a body is to attach them via small particles, or backpacks, to macrophage cells which are travelling to that section. Notably, this can be utilized to treat cancer which is highly difficult to get drug molecules into the right location. Researchers at University of Colorado Boulder, University of Florida used  PLGA-Rhodamine (AV011) from PolySciTech division of Akina, Inc. (www.polyscitech.com) as part of creating magnetic backpacks to specifically bind to cellular components. This research holds promise to provide for an additional cancer treatment option. Read more: Day, Nicole B., Christopher R. Orear, Ambar C. Velazquez-Albino, Hayden J. Good, Andrii Melnyk, Carlos M. Rinaldi-Ramos, and C. Wyatt Shields IV. "Magnetic Cellular Backpacks for Spatial Targeting, Imaging, and Immunotherapy." ACS Applied Bio Materials (2023). https://pubs.acs.org/doi/abs/10.1021/acsabm.3c00720

“Adoptive cell transfer (ACT) therapies are growing in popularity due to their ability to interact with diseased tissues in a specific manner. Disc-shaped particles, or “backpacks”, that bind to cellular surfaces show promise for augmenting the therapeutic potential of adoptively transferred cells by resisting phagocytosis and locally releasing drugs to maintain cellular activity over time. However, many ACTs suffer from limited tumor infiltration and retention and lack a method for real-time spatial analysis. Therefore, we have designed biodegradable backpacks loaded with superparamagnetic iron oxide nanoparticles (SPIONs) to improve upon current ACT strategies by (i) controlling the localization of cell-backpack complexes using gradient magnetic fields and (ii) enabling magnetic particle imaging (MPI) to track complexes after injection. We show that magnetic backpacks bound to macrophages and loaded with a proinflammatory drug, resiquimod, maintain anticancer phenotypes of carrier macrophages for 5 days and create cytokine “factories” that continuously release IL-12. Furthermore, we establish that forces generated by gradient magnet fields are sufficient to displace cell-backpack complexes in physiological settings. Finally, we demonstrate that MPI can be used to visualize cell-backpack complexes in mouse tumors, enabling a potential strategy to track the biodistribution of ACTs in real time. KEYWORDS: adoptive cell transfer immunotherapy cancer drug delivery macrophage microparticle magnetic particle imaging”

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