PLGA from PolySciTech used in development of printable antibiotic coatings for orthopedic implants

 

Infections associated with surgical implantation can lead to significant patient morbidity and costs for extended treatment of the bacterial infection. The incidence of this varies but has been reported to be ~ 5.3% of cases with Staphylococcus aureus being the most common bacteria (https://pubmed.ncbi.nlm.nih.gov/28712173/). Researchers at Warsaw University of Technology, University of Helsinki, and Medical University of Warsaw used PLGA (AP081, AP041) from PolySciTech Division of Akina, Inc (www.polyscitech.com) to create a printable formulation of antimicrobial releasing surface coating for orthopedic implants. This research holds promise to reduce surgical infections from implant placement. Martinez Perez, David, Ines Reigada, Jayendra Z Patel, Jari Yli-Kauhaluoma, Leena Hanski, Michał Srebrzynski, Maciej Spychalski, Emilia Choinska, Adyary Fallarero, and Wojciech Święszkowski. "Drop on Demand Antimicrobial Printed Coatings Loaded with Dehydroabietic Acid Derivative to Prevent Orthopedic Implant Infections." Available at SSRN 4633087. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4633087

“For the first time, microvalve-based drop on demand (DOD) printing technology has been applied to develop antimicrobial coatings for orthopedic implants. Leveraging the highprecision deposition capabilities of DOD, coatings loaded with a novel biofilm inhibitor, N- (abiet-8,11,13-trien-18-oyl) cyclohexyl-L-alanine (DHA1), were fabricated on titanium coupons. The PLGA-PEG-DHA1 coatings exhibited significant efficacy in preventing Staphylococcus aureus adhesion, both in monoculture and in co-culture with HL-60 cells. Furthermore, the PLGA-PEGDHA1 coatings showed a sustained protective effect of the 30% DHA1-loaded coating over a 24- hour period. The PLGA-PEG-DHA1 coatings ensured safety with no cytotoxic effect observed on SaOS-2 mammalian cells, fostering tissue integration post-implantation. This study paves the way to produce multi-component DOD coatings combining various ink compositions, including different polymers, antimicrobial agents, or growth factors.”

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